Biobank 3 Hoorn Diabetes Care System Follow up

The Hoorn Diabetes Care System cohort (DCS) is a prospective cohort representing a comprehensive dataset on the natural course of T2D. The cohort consists of persons with T2D in primary care from the West-Friesland region of the Netherlands. Enrolment in the cohort started in 1998 and this prospective dynamic cohort currently holds >15.000 persons with […]

Early-HFpEF-2: early recognition and course of incipient heart failure

The prevalence of heart failure is increasing in the population, and in particular of heart failure with preserved left ventricular function (HFpEF). Little is known about HFpEF even though it affects 40% of people with heart failure, especially older women, people with type 2 diabetes and/or high blood pressure. For many of these people, the […]


The OMED2 (Optimization of Medication in Elderly with Diabetes) study was initiated to reduce excessive use of glucose-lowering medication (i.e. insulin and/or sulphonylureas) in older (≥ 70 years) type 2 diabetes (T2D) patients by means of a deprescribing programme (DPP). Excessive use of glucose-lowering medication can result in hypoglyceamia, whereas the benefits of a tight […]

Mg-MAC study

The Mg-MAC study involves a randomized controlled trial wherein the participants of the Early-HFpEF study are recruited to assess the effect of magnesium supplementation on vascular calcification and stiffness in adults (aged 50-80 years) with type 2 diabetes. The knowledge gained from this research may contribute to improved treatment of vascular calcification and stiffness in […]