Mg-MAC study

The Mg-MAC study involves a randomized controlled trial wherein the participants of the Early-HFpEF study are recruited to assess the effect of magnesium supplementation on vascular calcification and stiffness in adults (aged 50-80 years) with type 2 diabetes. The knowledge gained from this research may contribute to improved treatment of vascular calcification and stiffness in people with type 2 diabetes.

What does the study involve?
The study involves a total of four visits over a period of 6 months. Overall, the visits will take about 1.5 hours. Oral magnesium citrate supplements or placebo supplements have to be taken daily for 6 months. At screening and at the first follow-up after 3 months, participants will undergo a blood sampling for plasma magnesium concentrations and measurement of arterial stiffness. At baseline and at the second follow-up after 6 months, participants will undergo blood sampling for magnesium as well as cardiovascular biomarkers, will hand in a 24-hour urine collection and will undergo measurements of arterial stiffness. Dietary intake of magnesium will be assessed by a short food frequency questionnaire at the start of the study and the second follow-up after 6 months.

Study status
This study has finalized participant recruitment and is anticipated to be finalized in October 2024

Romain Meer (PhD-student) and Prof Joline Beulens

Romain Meer

For more information on this study, click here.