Current projects

Biobank 3 Hoorn Diabetes Care System Follow up

The Hoorn Diabetes Care System cohort (DCS) is a prospective cohort representing a comprehensive dataset on the natural course of T2D. The cohort consists of persons with T2D in primary care from the West-Friesland region of the Netherlands. Enrolment in the cohort started in 1998 and this prospective dynamic cohort currently holds >15.000 persons with T2D. In subgroups of the cohort, biobanking and additional measurements have been performed to obtain information on, for example, lifestyle, depression and genetics. The 3rd

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Early-HFpEF-2: early recognition and course of incipient heart failure

The prevalence of heart failure is increasing in the population, and in particular of heart failure with preserved left ventricular function (HFpEF). Little is known about HFpEF even though it affects 40% of people with heart failure, especially older women, people with type 2 diabetes and/or high blood pressure. For many of these people, the diagnosis is only made at the time of hospital admission or when physical complaints already appear, despite the fact that abnormalities in the heart have

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Mg-MAC study

The Mg-MAC study involves a randomized controlled trial wherein the participants of the Early-HFpEF study are recruited to assess the effect of magnesium supplementation on vascular calcification and stiffness in adults (aged 50-80 years) with type 2 diabetes. The knowledge gained from this research may contribute to improved treatment of vascular calcification and stiffness in people with type 2 diabetes. What does the study involve?The study involves a total of four visits over a period of 6 months. Overall, the

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The OMED2 (Optimization of Medication in Elderly with Diabetes) study was initiated to reduce excessive use of glucose-lowering medication (i.e. insulin and/or sulphonylureas) in older (≥ 70 years) type 2 diabetes (T2D) patients by means of a deprescribing programme (DPP). Excessive use of glucose-lowering medication can result in hypoglyceamia, whereas the benefits of a tight glucose regulation in patients with a very limited lifespan is questionable. For this reason, the Dutch College of General Practitioners state that higher glucose levels

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2024 Remmelzwaal S, Yeung SMH, Blom MT, de Borst MH, Elders PJM, Beulens JWJ. Increased interleukin-6 is associated with higher risk of heart failure in people with type 2 diabetes. ESC Heart Fail. Published online March 28, 2024 Article 2023 Allesøe RL, Lundgaard AT, Hernández Medina R, Aguayo-Orozco A, Johansen J, Nissen JN, et al Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models Nature Biotechnology 2023 Article Allesøe RL, Lundgaard AT, Hernández Medina R, Aguayo-Orozco A, Johansen J, Nissen

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Past projects


Providing new perspectives on obesity Aim project SPOTLIGHT was conducted in the period 2012 to 2016 and has systematically defined the factors necessary for establishing effective health promotion approaches. Different levels in varying contexts were taken into account – individual, family, organisational, and environments that can change behaviour, lifestyles, and life skills to sustainably reduce obesogenic behaviours in an innovative way. This was done by a multidisciplinary consortium involving 13 organisations in eight European countries – Belgium, Denmark, France, Hungary, the Netherlands,

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Supreme nudge

Nudging and pricing in supermarket setting. Aim project The aim of this project was to investigate the effects of nudging and pricing in a supermarket setting, combined with a mobile physical activity app, on energy balance-related behaviours and cardiometabolic risk factors in adults with low socioeconomic status. Targeting the environment in which health behaviour choices are made can reduce cardiometabolic risk. Supermarkets form one of the most important point-of-choice settings with the potential to directly influence purchasing behaviors. ‘Nudges’ (small

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The Early HFpEF study

The early heart failure with preserved ejection fraction study Aim The early HFpEF study aims to investigate the association of clinical characteristics, natriuretic peptides, vascular calcification, vascular stiffness and functional cardiac abnormalities as detected by echocardiography with the presence of heart failure with preserved ejection fraction in persons with diabetes mellitus type 2. Heart failure is the second most common cardiovascular complication among patients with type 2 diabetes and approximately 70% of the people with diabetes type 2 and heart failure

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